Pharmacologic Category: Electrolyte Supplement, Magnesium Salt

Uses : Mood ( improved relaxation ) Adrenal ( decreases cortisol ) Stress (  decreases stress ) musculoskeletal ( bone formation ) Anti-aging ( DNA synthesis ) Neurotransmitter ( sleep improvements ) Cardiovascular ( blood pressure benefits ) GI ( bowel regulation ) Respiratory ( pulmonary function )

Recommended for the following top  complaints:Alcoholism, poor diet, poorly controlled diabetes, those taking diuretics ,high stomach acid, GI dysfunction, Magnesium deficiency, heart disease, high blood pressure, anxiety and stress, insomnia

Mechanism of Action: Magnesium is important as a cofactor in many enzymatic reactions in the body involving protein synthesis and carbohydrate metabolism (at least 300 enzymatic reactions require magnesium). Actions on lipoprotein lipase have been found to be important in reducing serum cholesterol and on sodium/potassium ATPase in promoting polarization (eg, neuromuscular functioning).

Basic Information: Magnesium chloride is a mineral important in maintaining multiple nerve, cell, bone, muscle and heart functions such as energy synthesizing, dna creation, bone density support and much more.  Magnesium, a divalent cation as well as the second most common intracellular cation in the body after potassium, plays a fundamental role in a significant number of enzymatic reactions pertaining to nucleic acid synthesis and energy metabolism.1 Additionally, magnesium is important for glycolysis, oxidative phosphorylation, osteogenesis and bone ossification, and RNA as well as DNA synthesis. Magnesium also is integral in the regulation of the enzyme Na+/K+ ATPase which controls the intracellular as extracellular flow of sodium and potassium in living cells. Generally, magnesium is typically found in food sources such as cereals and legumes, and is excreted from the body.Clinically, magnesium is administered in the body as magnesium salts. Magnesium chloride is one of the most common magnesium salts that is used clinically. Highly water-soluble, it comprises a magnesium halide bound to two inorganic chloride ions. Administered parenterally, some clinical indications for the use of magnesium chloride include peritoneal dialysis, total parenteral nutrition (TPN), fluid and electrolyte replacement, and the management of cardiovascular diseases such as congestive heart failure, supraventricular tachycardia, ventricular arrhythmia, and atherosclerosis. Magnesium chloride is expressed in breast  milk in lactating mothers and is classified by the Food and Drug Administration as a pregnancy category C drug; it should only be administered in pregnant mothers when the benefits of administration outweigh the risks.

Benefits

Mood/Adrenal/Stress Health: Magnesium calms the nervous system and has been shown to play a role in the regulation of the HPA axis.Magnesium promotes relaxation by decreasing the activity of glutamate, the primary excitatory (stimulating) neurotransmitter in the brain. Magnesium blocks glutamate from binding to its receptor, allowing for an increase in GABA activity, which activates the sleep cycle. Within the HPA axis, the body’s stress response system, magnesium has also been shown to decrease the release of the stress hormone cortisol. This helps improve relaxation and decreases stress levels. Numerous studies have demonstrated that people who suffer from mental health disorders are deficient in magnesium.

Musculoskeletal : Magnesium is  involved in bone formation and influences the activity of osteoblasts and osteoclasts, cells responsible for the breakdown and formation of bone, also impacts concentrations of parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis.Magnesium works on smooth muscle relaxation which contributes to a decreased risk of migraines. It also helps improve lactic acid clearance which is useful for muscle recovery.

Anti-Aging/Neurotransmitter Support: It plays a fundamental role in a significant number of enzymatic reactions pertaining to nucleic acid synthesis and energy metabolism.Additionally, magnesium is important for glycolysis, oxidative phosphorylation, osteogenesis and bone ossification, and RNA as well as DNA synthesis.

Cardiovascular Health: Studies to date have found that magnesium supplementation maintains healthy blood pressure levels.Calcium is essential to the contraction of muscles, while magnesium aids muscle relaxation. Insufficient magnesium levels can contribute to constriction of the muscles in blood vessels and trigger changes in blood pressure levels. Insufficient magnesium levels can lead to an increased risk of cardiac arrhythmias.  It is also an integral for the transport of insulin from the bloodstream to cells. Increasing magnesium levels has been shown to maintain normal blood sugar levels.

GI Health:Magnesium is also used to treat high stomach acid in the body, preventing stomach upset, heartburn, and acid indigestion as well as supports bowel regulation/reduces constipation.

Sleep Support: Magnesium calms the nervous system and blocks glutamate from binding to its receptor, allowing for an increase in GABA activity, which activates the sleep cycle. 

Respiratory Support: Magnesium is also known to play a prominent role in the respiratory system.There are several studies that have been conducted which demonstrate that hypomagnesemia is associated with increased incidence of wheezing, airway hyperreactivity, and impaired lung function. Pulmonary function values are decreased in individuals with magnesium deficiency in contrast to their normal counterparts. For patients with acute severe asthma, the use of parenteral magnesium is part of the treatment protocol in an inpatient setting if there is no response to traditional first-line treatment modalities

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

• Injection:

• Flushing.

• Sweating a lot.

• Dizziness or passing out.

• Feeling sluggish.

• Feeling cold.

• Shortness of breath.

What are some other side effects of this drug?

• All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Sweating

• Stomach upset

• Diarrhea

• Flushing

• Respiratory depression

• Hypotension

• Allergic reaction

• These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

• You may report side effects to your national health agency.

General drug facts

• • If your symptoms or health problems do not get better or if they become worse, call your doctor.

• • Do not share your drugs with others and do not take anyone else's drugs.

• • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, or other health care provider.

• • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.