SPRAVATO® (esketamine) Patient Pre-Treatment & Post-Treatment Instructions

BEFORE YOUR SPRAVATO® TREATMENT

• Eating & Drinking

  • Do not eat solid food for at least 2 hours before your appointment.
  • Do not drink liquids for at least 30 minutes before your appointment.
    • This helps reduce nausea or vomiting during treatment.

• Medications & Substances

  • Take your regular prescribed medications unless your provider instructs otherwise.
  • Avoid alcohol on the day of treatment.
  • Do not use recreational drugs on treatment days.
  • Inform your provider of any new medications, especially:
    • Benzodiazepines
    • Opioids
    • Stimulants
    • Blood pressure medications

• Transportation

  • You must arrange a ride home.
  • You may not drive, bike, or operate machinery the same day as treatment.
  • Ride-share services are acceptable only if approved by your clinic.

• Health Status

  • Notify the clinic if you are experiencing:
    • Illness, fever, or infection
    • Significant anxiety or panic symptoms
    • Changes in blood pressure
    • Pregnancy or plans to become pregnant

• DURING YOUR TREATMENT

  • SPRAVATO® is self-administered as a nasal spray under staff supervision.
  • You will remain in the clinic for at least 2 hours for monitoring.
  • You may experience:
    • Dissociation or feeling “detached”
    • Dizziness or lightheadedness
    • Sleepiness
    • Changes in perception
  • These effects are expected and temporary.
  • Staff will monitor your blood pressure, comfort, and safety throughout the visit.

• AFTER YOUR SPRAVATO® TREATMENT

  Same-Day Restrictions

  For the rest of the day, do NOT:

  • Drive or operate vehicles
  • Use heavy machinery
  • Make important decisions
  • Consume alcohol
  • Engage in strenuous activity

  Plan to rest and take it easy for the remainder of the day.

  Eating & Hydration

  • You may resume eating once nausea has resolved.
  • Start with light foods and hydrate slowly.

  Emotional & Mental Effects

  • Mood changes, emotional sensitivity, or fatigue can occur.
  • Some patients feel calm, reflective, or emotionally open.
  • If distressing thoughts or symptoms arise, contact the clinic.

  When to Call the Clinic

  Contact your provider if you experience:

  • Persistent vomiting
  • Severe headache
  • Chest pain
  • Shortness of breath
  • Severe anxiety or confusion
  • Worsening depression or suicidal thoughts

IMPORTANT REMINDERS