Low-Dose Naltrexone (LDN) in Sandy, UT

Naltrexone is used as an off-label treatment in low doses for several chronic immune-modulated disorders in many countries. Although only small-scale clinical trials have been performed, these suggest efficacy in several diseases, including Crohn’s disease, fibromyalgia, and Gulf War Illness. Despite numerous internet reports of response to low-dose naltrexone (LDN), no clinical trials exist in people with chronic fatigue syndrome. This condition is characterized by chronic profound fatigue, post-exertional malaise, pain, and autonomic and neurocognitive disturbances. This series of three case reports compiled by people with long-term ill-health due to chronic fatigue syndrome shows the range of responses they observed when taking LDN, from life-changing to a reduction in some symptoms only. Treatment doses ranged from 4 to 12mg. Clinical trials may be warranted to explore the potential use of naltrexone in people with these debilitating illnesses, which currently have no licensed treatments available.

The mechanism of action for naltrexone at low doses in this disease group is unknown. It is possibly due to the rebound of endorphins following short-term suppression, or to direct action that suppresses inflammation induced by microglia. There have been no formal dosing studies of naltrexone at low doses in any disorder. Therefore, although the dose of 3–4.5 mg is established in clinical practice, some practitioners use 9 mg (Klimas, personal communication, 2017) or higher in chronic fatigue syndrome. Causality and dosing need further studies.

The FDA approved weight loss medication naltrexone HCL to treat overweight and obese patients. Low-dose Naltrexone works to suppress your appetite. Combination weight loss medications like these may improve your mood and suppress your sugar and carb cravings to stop overeating once and for all.

Take low-dose naltrexone to:

• Regulate appetite: Naltrexone helps normalize your metabolism, matching your appetite to resting energy expenditures.
• Reduce insulin resistance: Naltrexone modulates insulin resistance at the cellular level, which may lead to weight loss.
• Improve sleep: Lack of sleep disrupts your body’s hormonal system, which can lead to weight gain. Naltrexone combats this unhealthy cycle.
• Improve mood: Combination LDN weight loss medications trigger an increase in serotonin and dopamine production, which decreases anxiety and stress and reduces emotional eating.

Patient Drug Information

• We advise taking LDN in the evening before bed but not too late into the night-
• Low Dose Naltrexone (LDN) refers to prescribed doses below 10mg per day (4.5mg/daily is most common)
• At low doses of 10mg per day or less, LDN is shown to reduce chronic inflammation, autoimmunity, obesity, fatigue, and chronic pain
• Used successfully for over 40 years with an outstanding safety record

Most Common LDN Side Effects

• Vivid dreams
• Mild anxiety
• Insomnia
• Headache

During the first three to five days of taking LDN, you may experience mild to moderate levels of the above side effects. Side effects typically diminish on their own by day five. If you experience side effects, you may reduce them by reducing your dose by half (typical dosing is 4.5 mg; ½ a tab would be 2.25 mg) for the first two weeks, then gradually increase to the 4.5 mg dose.

Note: Please stop taking any dosage of Naltrexone a minimum of 48 hours before any surgical procedure or medical diagnostic procedure requiring sedation, such as surgery or a colonoscopy. If you are not sure if you need to stop Naltrexone, please ask your doctor to order the test or procedure. Additionally, Naltrexone cannot be taken in conjunction with opioids(narcotics)/painkillers. If you need to stop taking Naltrexone for a surgery, and accompanying painkillers are prescribed, you may resume LDN only 48 hours after you take your last painkiller.

Possible Drug Interactions: Tell your doctor and pharmacist if you are allergic to naltrexone, any of the ingredients of LDN tablets, or any other medications. Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: amiloride (Midamor); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); beta-blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, InnoPran); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), nimodipine (Nymalize), nisoldipine (Sular), and verapamil (Calan, Covera, Verelan, in Tarka); cimetidine (Tagamet); digoxin (Lanoxin); diuretics (‘water pills’); furosemide (Lasix); hormone replacement therapy; insulin or other medications for diabetes; isoniazid (Laniazid, in Rifamate, in Rifater); medications for asthma and colds; medications for mental illness and nausea; medications for thyroid disease; morphine (MS Contin, others); niacin; oral contraceptives (‘birth control pills’); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); quinine; ranitidine (Zantac); triamterene (Dyrenium, in Maxzide, others); trimethoprim (Primsol); or vancomycin (Vancocin). Your doctor may need to adjust your medication doses or monitor you closely for side effects.

Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

• Individualized Treatment: Our experienced medical professionals will work closely with you to develop a personalized LDN treatment plan tailored to your specific needs and health goals. We take into account your unique medical history, current health condition, and any other medications you may be taking.
• Holistic Approach: We believe in a holistic approach to healthcare. LDN therapy can be an integral part of a comprehensive treatment plan that may include lifestyle modifications, dietary adjustments, and other therapies to enhance your overall well-being.
• Ongoing Support: Our dedicated team is committed to supporting you throughout your LDN journey. We provide regular follow-up appointments to monitor your progress, address any concerns or questions, and adjust your treatment plan as needed.
• Evidence-Based Medicine: LDN has gained attention in recent years, and numerous studies have shown its potential benefits in various health conditions. We stay up to date with the latest research and incorporate evidence-based practices into our treatment protocols.

*We often add low-dose naltrexone therapy to a variety of our programs at no additional cost, such as our weight loss program!